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KMID : 0357520170400010135
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Journal of Radiological Science and Technology
2017 Volume.40 No. 1 p.135 ~ p.142
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Effect of Selenium on the Thyroid Antioxidative Metabolisms in Rat Model by Ionizing Radiation
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Choi Hyung-Seok
Choi Jun-Hyeok
Jung Do-Young
Kim Jang-Oh
Shin Ji-Hye
Min Byung-In
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Abstract
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Selenium (Se), which is natural materials existing was known as an important component of selenoprotein, one of the important proteins responsible for the redox pump of a living body. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the thyroid gland was used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium (Se) through changes of blood components, thyroid hormones (T3, T4), antioxidant enzyme (GPx) activity and thyroid tissue changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet)(p<0.05). The activity of Glutathione Peroxidase (GPx), the antioxidant enzyme, and the activity of the target organ, thyroid hormone (T3, T4), also showed significant activity changes (p<0.05). In the observation of tissue changes, it was confirmed that there was a protective effect of thyroid cell damage which caused the cell necrosis by radiation treatment. Therefore, it is considered that selenium(Se) can be utilized as a radiation defense agent by inducing immunogenic activity effect of a living body.
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KEYWORD
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Selenium , T3.T4 , Thyroid gland , GPx , Radioprotector
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